Aids in the control of clinical signs associated with E. coli mastitis. Subcutaneous (SC) 5 mL dose given at dry off, 30 days later, and within 2 weeks of freshening. Particularly valuable in recently freshened, low-SCC and high-production cows, which may be more susceptible to infection by E. Coli. Three-dose vaccination program helps deliver protection and safety. No formulation changes to the product have been made.