For vaccination of healthy cattle to aid in the prevention of clinical mastitis caused by E. coli and the effects of endotoxemia in cattle due to Escherichia coli, Salmonella typhimurium, Pasteurella multocida and Pasteurella haemolytica. Inject 2 mL into the musculature of healthy cattle. Repeat in 2 or 3 weeks. Administer a 2 mL booster dose annually. Recommended for vaccination of cows during the dry period and heifers during the third trimester of pregnancy.